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Optimum Overall Treatment Time in Radiation Oncology

How to Stop Worrying About Time-Dose Evaluations and Learn to Love Linear Quadratics

Jack Fowler (author) Alexandru Dasu (author)
Iuliana Toma-Dasu (author)

ISBN: 9781930524736

Publication Date: Jan 2015

Format: Paperback

The late John "Jack" Fowler was a busy radiation biology researcher and teacher who wrote 581 papers over the last 65 plus years. He also received nearly every honour the medical physics field can bestow. This book sums up the key concepts relating to optimum fractionation in radiation therapy that interested him throughout his life. This book is a quick, informative, and enjoyable read.
£41.95

Temporarily out of stock: usually despatched in 10-14 days

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The late John "Jack" Fowler was a busy radiation biology researcher and teacher who wrote 581 papers over the last 65 plus years. He also received nearly every honour the medical physics field can bestow. This book sums up the key concepts relating to optimum fractionation in radiation therapy that interested him throughout his life. Just under 100 pages in length, this book is a quick, informative, and enjoyable read.
Pages 93
Dimensions 229 x 152
Date Published 30 Jan 2015
Publisher Medical Physics Publishing
Subject/s Oncology   Radiology   Radiotherapy   Medical physics   Nuclear medicine  
  • Optimum Overall Treatment Time in Radiation Oncology
  • Chapter 1: The Origins of Linear Quadratics
  • 1.1 A 60+ Year Quest to Find How Fractionation Really Works, 1950 - 2014
  • 1.2 The Linear Quadratic Concept and its Relevance to Clinically Sized Doses
  • in Radiotherapy
  • 1.3 Time to Think
  • Chapter 2: LQ Modeling
  • 2.1 The Simplest Modeling
  • 2.2 The Seven Steps to Linear Quadratic Heaven: A Brief Summary
  • 2.3 The Details
  • Chapter 3: Dose and Effectiveness
  • 3.1 Biologically Effective Dose
  • 3.2 Relative Effectiveness (RE)
  • 3.3 Overall Treatment Time and Tolerances
  • 3.3.1 Late Normal Tissue Complications
  • 3.3.2 Acute Mucosal Tolerance
  • Chapter 4: Normalized Total Dose
  • 4.1 Converting from BED to NTD or EQD
  • 4.2 Gamma Slopes, the Standard of Prescription of Estimates of BED or NTD
  • 4.3 How to Evaluate a New Schedule - a Summary
  • Chapter 5: A Review of Schedules
  • 5.1 Some of the Best-known Schedules
  • 5.2 Standard Fractionation
  • 5.3 Hyperfractionation
  • 5.4 RTOG 90-03
  • 5.5 Initially Too Hot in Table 5 - 1
  • 5.6 General Considerations
  • 5.7 The Danish Six Fractions a Week
  • 5.8 Appropriateness of LQ Modeling
  • Chapter 6: How to Obtain Curves with Peaks of Optimum Overall Treatment Times
  • 6.1 Differences Between 7 Days and 3 - 4 Weeks in Tk
  • 6.2 The Problem of Finding an Optimum Overall Time
  • Chapter 7: Time and Repopulation
  • 7.1 Results vs Days of Overall Time
  • 7.1.1 Two Fractions a Day Give More Tumor Log Cell Kill than One Fraction a Day
  • 7.1.2 The Effect of Assuming Faster or Slower Repopulating Rates
  • 7.2 Discussion: The Exceptional Cases of Very Fast Repopulation
  • Chapter 8: Should We Ever Use One Fraction a Day?
  • 8.1 Discussion: Is One Fraction a Day Still to Be Used?
  • 8.2 Main Conclusions
  • 8.2.1 Conclusion #1: 2F/Day is Nearly Always Better than 1F/Day
  • 8.2.2 Conclusion #2: Investigate Repopulation Rates for Use in Longer Schedules
  • 8.3 Discussion: Smaller and Smaller Fractions
  • 8.4 Discussion: How Long Is Really Too Long?
  • Chapter 9: How Short is Too Short?
  • 9.1 Introduction
  • 9.2 Acute Tolerance Calculations Are Also Worth Doing
  • Chapter 10: Recovery
  • 10.1 Incomplete Recovery
  • 10.2 Incomplete Recovery as a Loss of Effect in Prolonged Fractions
  • Chapter 11: The Influence of Inter-patient Heterogeneity
  • 11.1 Introduction
  • 11.2 Tumor Control Probability Modeling
  • 11.3 Results and Discussion
  • 11.4 Summary
  • Chapter 12: Final Thoughts
  • Photographs
  • Glossary
  • References and Additional Resources

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